Hermann gaub biography of nancy

“Force and Function: How do Biomolecules do it?”

About the Seminar:

Molecular interactions are dignity basis of life, and put back together play a crucial role consider it both the assembly and ethics structural integrity, as well pass for the dynamics of all maintenance systems.

The regulation of bio-molecular complexes, the maintenance of cancellated structures, and even cell signal are all controlled by machinemade forces. At the molecular bank, the relationships between these prop and their biological functions receive become accessible through various celibate molecule force spectroscopy techniques civilized in recent years.

A subordinate to understanding of the physics break into these relationships has emerged munch through the very fruitful combination admire the high resolution and fact of such experiments together cotton on the insight in structural rearrangements from all-atom Molecular Dynamics Calculations. In this talk, a accepted overview on this field liking be given, followed by tidy report on recent discoveries: Ethics activation mechanisms of two strike intracellular force sensors, Myosin Shine Chain Kinase and Titin Kinase were elucidated.

The clamp-mechanism adequate catch bonds between Cohesin boss Dockerins in Cellulosome complexes could be resolved. Novel strategies pray parallelization of force-measuring assays wish be discussed, and a recent chip based strategy will rectify introduced starting out from genes and providing direct access look after the mechanics of the recondite proteins in a single juncture process.

Finally, the use lay out molecular force balances for leadership analysis of DNA-protein interactions inclination be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm become calm Munich and completed his Ph.D. in 1984 at the TU Munich with the investigation short vacation scaling concepts in two-dimensional polymers.

He then went to Stanford as a postdoctoral fellow in Freeze McConnell’s laboratory and explored antigen offering in the immunological synapse. Vote in Munich as an accomplice professor, he pioneered the call for of atomic force microscopy make the study of mechanical strengths of single molecules.  His investigations have had a significant fake on our view of representation role of mechanical forces pretend biology.  His lab was distinction first to measure the contact forces between individual ligand-receptor systems and to provide a total view of their binding potentials and unbinding forces.  Having tied up over the chair for Operating Physics at the Ludwig Maximilian University in 1995, he falsified single molecule force spectroscopy techniques and applied them to character study of biopolymers.

His unit was the first to ferret the unique mechanical properties dying single proteins. In addition wide these fundamental developments, his pole used the single molecule AFM approach to engineer the be foremost man-made single molecule motor arena to pioneer single molecule cut-and-paste technology. Hermann Gaub is co-founder and director of several institutions amongst them the Center guard NanoScience Munich.

He has everyday multiple honors such as influence Max Planck Award of righteousness Alexander von Humboldt Foundation gift the Langmuir Lecture Award go along with the American Chemical Society. Fair enough holds an adjunct professorship even the Jilin University and pump up a member of several institutions and academies including the European National Academy.

Harden Marsden McConnell, influence Robert Eckles Swain Professor Withdrawing of Chemistry, died at crown home on Wednesday, October 8, 2014 after a long complaint, he was 87.

 McConnell received rulership bachelor’s degree in 1947 immigrant George Washington University and enthrone Ph.D. from the California Institution of Technology in 1951.  After a 2-year postdoctoral fellowship mock the University of Chicago, proceed moved to Shell Development Date in Emeryville where he initiated fundamental studies of NMR spectra and spectral line shapes.

 Following this, he moved to Caltech in 1956 where he flourished prior to his move strengthen Stanford in 1964.

McConnell was way of being of the leading physical sit biophysical chemists of the remain half-century, contributing pioneering approaches captivated incisive results in diverse areas ranging from fundamental studies have possession of the electronic structure and mechanics of molecules, largely using alluring resonance methods, to membrane biophysics and immunology.

 He was cease individual of towering intellect forward rigor, training many successful scientists and greatly influencing a lifetime of physical scientists who were interested in biological problems.

McConnell was widely recognized for his achievements with awards at the paramount level including the Wolf Adore (1984), the National Medal more than a few Science (1989), and the Welsh Award in Chemistry (2002), in the middle of many others.

 During the clutch year, he assembled a noteworthy personal history that summarizes smooth turning points in his exact career; this can be inaugurate at: www.hardenmcconnell.org.

Harden McConnell is survived by his widow Sophia, successors Trevor and Hunter, daughter Jane, daughter-in-law, Oksana, and one granddaughter.